Recent long-term studiesin mice, however, support a direct role of p63 and p73 on tumour suppression.A recent K.O. mouse specific for the TA isoform of p73, however, shows anintermediate phenotype between the full p73 -/- and p53 -/-regarding tumour formation, supporting a role of p73 in tumour suppression [10].Additionally, p63 and p73 can cooperate with p53 in tumour suppression [11]. This evidence concerns the gene TP53 and neoplasm.