CNR1 and inflammatory bowel disease: [34] Interestingly, an earlier genome-wide family-based linkage study found an association of this region with celiac disease [35]. We recently demonstrated that celiac disease and UC (but not CD) share another common susceptibility locus on chromosome 4q27. [36] Although none of the recent genome-wide association studies demonstrated the CNR1 gene as a major IBD susceptibility gene, a previous genome scan in 260 IBD-affected relative pairs found nominal evidence for linkage of IBD to loci on chromosome 6q (lod = 2.21 between D6S2436/D6S305). [37]