The instant Gardos channel-mediated response observed upon membrane deformation under the patch pipette (Figures 1 and 2A), suggests that calcium entering the cell via PCa, driven by the steep inward Ca2+ gradient, induces a new pump-leak balance with [Ca2+]i high enough to elicit maximal activation of the Gardos channels. Here, KCNN4 is linked to posterior cortical atrophy.