RB1 and retinoblastoma: Retinocytoma is considered to be a rare benign phenotypic RB1 gene mutation and carries similar genetic implications as germinal retinoblastoma.[1, 2, 5] In familial cases, various members of a family may present with either retinocytoma or retinoblastoma or even a combination of both between the two eyes.[1, 2, 7] Histologically, retinocytoma is composed of benign appearing cells with numerous fleurettes and lack of necrosis or mitotic activity.[5] Localized deposits of calcium inside the tumor or even in the vitreous may be present.[2, 8]