CXCL8 and lung disorder: Although ZnO induces IL-8 expression in bronchial epithelial cells and IL-8 plays a critical role in the pathogenesis of pulmonary disorders (Blanc et al. 1993; Kuschner et al. 1997, 1998; Standiford et al. 1993), the mechanisms underlying ZnO-induced IL-8 expression have not been well characterized.