Selective Cox-2 inhibitor use was not associated with breast cancer occurrence among individuals with (OR = 1.12, 95% CI = 0.86 to 1.44) or without (OR = 1.07, 95% CI = 0.98 to 1.17) a history of NSAID use before beginning sCox-2 inhibitor use. The gene discussed is PTGS2; the disease is breast carcinoma.