In the present overview, we mainly recapitulate some molecular features of brain A2ARs and the ability of the A2AR to integrate several neurotransmission and signaling pathways that might be relevant to the potential therapeutic interest of psychopharmacology, particularly in psychostimulation, drug addiction, anxiety, depression, psychiatric disorder, e.g. schizophrenia, and in learning and memory [185]. The gene discussed is ADORA2A; the disease is major depressive disorder.