BDNF and epilepsy: It may happen that A2A receptors prove detrimental in epilepsy due to their ability to enhance excitability, and therefore these receptors need to be concomitantly blocked in adenosine augmentation therapies; conversely, it may happen that these receptors facilitate the positive influences of BDNF upon neuronal survival and therefore, an A2A receptor mediated favourable influence would add to the A1 receptor mediated one.