HHIPL2 and cancer: In addition, the overexpression of HHILP2 was significantly associated with copy number gain (p < 0.05) as the expression of HHIPL2 was 17.4-fold higher in cancer samples with copy number gain of HHIPL2 (g1) than in cancer samples with normal copy number of this gene (g0) (Tables 3 and 4).