ERBB2 and cancer: A literature search showed that 50 of these genes (37 up- and 13 down-regulated genes) had previously been reported to have mutations, polymorphisms, copy number and/or expression changes in malignant tumors, and 4 of the genes (ERBB2, JAK2, LIFR, and ZNF331) are included in the Cancer Gene Census of the Wellcome Trust Sanger Institute [30].