Interestingly, numerous genes (including MAP3K7IP2, SUMO4, p34/ZC3H12D, LATS1, RAET1 cluster, ULBP cluster, AKAP12, ESR1, MYCT1, VIP, TIAM2, SOD2, WTAP, MAS1, SLC22A cluster, IGF2R, etc.; see see additional file 1) found within the FOXM1B-induced LOH at 6q25.1-6q25.3, have been previously linked to oncogenesis of various human cancers [40,42-53]. This evidence concerns the gene ESR1 and cancer.