FOXM1 and osteosarcoma: More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1, regulates expression of a large array of G2/M-specific genes, such as Plk1, Cyclin B2, Nek2 and CENP-F, and plays an important role in maintenance of chromosomal segregation and genomic stability [3].