SLIT2 appears to be a candidate for a colon cancer suppressed gene, since it is often inactivated by LoH and hypermethylation [27] and its receptor, ROBO1, has been implicated in colon cancer [28], although the underlying mechanism of the SLIT-ROBO involved tumor growth remains obscure. This evidence concerns the gene ROBO1 and malignant colon neoplasm.