Other evidence suggests that CYP2J2 and EETs, which lead to phosphorylation of the epidermal growth factor receptor and the subsequent activation of downstream phosphoinositide 3-kinase (PI3K)/AKT and MAPK signaling pathways, suppresses apoptosis and up-regulates proliferation in carcinoma [23]. The gene discussed is CYP2J2; the disease is carcinoma.