One of the paths influencing proliferation starts at the well-known oncogene MET (which encodes a Met tyrosine kinase and is present in both colorectal and renal cancer), and includes a sequence of genes that all have significant TIF scores: GAB1, SHP2, ERK, AP1 (TIF = 1.14, 1.23, 1.15, and 1.16, respectively). The gene discussed is MET; the disease is renal carcinoma.