NOS2 and Stroke: In stroke-induced brain injury cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS), are produced by a variety of activated cell types; endothelial cells, microglia, neurons, platelets, monocytes, macrophages and fibroblasts [5].