TFAP2A and chronic myelogenous leukemia, BCR-ABL1 positive: Amongst the remaining 3 genes, TFAP2A (63%) and EBF2 (57%), demonstrated statistically significant methylation in BC vs CP-CML (P < 0.05), whilst TRCP4 was more frequently methylated in BC (50%) compared to CB-CML (18%) samples but it did not reach statistical significant (P= 0.06) (Table 2).