Moreover, healthy young, middle aged and elderly carriers of the KIBRA rs17070145 T-allele exhibited a clear advantage in delayed episodic recall compared to individuals lacking the T-allele [15,16], but a further study in a community AD population showed an association of the KIBRA rs17070145 T-allele with an increase AD risk [17], thus resulting inconsistent with previous findings in healthy subjects. This evidence concerns the gene WWC1 and Alzheimer disease.