Interestingly, circulating HER-2 concentration was significantly increased in men (11.9 ± 1.9 vs. 8.5 ± 2.1 ng/ml, p < 0.0001) in parallel to insulin resistance (HOMA value 5.2 ± 3.2 vs. 2.18 ± 1.5 in men and women, respectively, p = 0.03). This evidence concerns the gene ERBB2 and Insulin resistance.