The presence of cells containing periodic acid-Schiff positive granules which are immunohistochemically positive for pancreatic enzymes (such as trypsin, chymotrypsin and lipase) as well as for endocrine markers (chromogranin and synaptophysin), together with evidence of endocrine hormones are indicative of tumor differentiation toward both acinar and endocrine cell carcinoma [7]. The gene discussed is SYP; the disease is neoplasm.