Furthermore, in the euglycemic hyperinsulinemic clamp test, glucose infusion rate (GIR) in Ad-DN-JNK-treated mice was higher than that in Ad-GFP-treated mice, indicating that suppression of the JNK pathway in the liver reduces insulin resistance, and thus ameliorates glucose intolerance in the db/db mice. The gene discussed is MAPK8; the disease is Insulin resistance.