Kv1.3 activity appears to be critical for the function of effector memory T-cells, while central memory T-cells signal through separate calcium-dependent potassium channels: KCa3.1.[66] Since effector memory T-cells are implicated in autoimmune disorders and are abundantly present in MS brain tissue, targeting the Kv1.3 receptor may be a means of achieving more specific immunosuppression, without causing inhibition of normal immune function. The gene discussed is KCNN4; the disease is Autoimmunity.