Studies in humans have shown an increase in inducible Nitrogen oxide synthetase in the CSF of patients with active MS.[19] Cytokines have also been implicated in decreased axonal conduction, specifically Tumor Necrosis Factor α and Interferon-γ.[20] This also, in part, explains transient worsening of MS symptoms during fever and concurrent infection. Here, TNF is linked to myeloid sarcoma.