MBP and acute disseminated encephalomyelitis: However, it should be noted that MBP fragment 43–88 was notably absent in the CSF in one study in 8/10 patients with ADEM a disorder with disseminated white matter injury,.[55] It has been suggested that detection of specific MBP fragments may be more specific for MS exacerbations as the size of MBP seen in the CSF of patients with cerebrovascular events is considerably different from the fragments observed from CSF of patients with MS.