In 1942, Elvin Kabat described elevated “gamma globulin” in CSF from patients with MS for the first time.[7] While at Columbia University, New York, he described using the then novel technique of agarose gel electrophoresis to show abnormal elevation of gamma globulins but not albumin or transferrin in the CSF from patients with multiple sclerosis, but not from control subjects. The gene discussed is TF; the disease is myeloid sarcoma.