The present criteria for diagnosis specifies optic neuritis and acute myelitis and at least two of three supportive criteria, (a contiguous spinal cord MRI lesion extending over three vertebral segments, brain MRI not meeting the diagnostic criteria for multiple sclerosis, and NMO-IgG/AQP4 antibody seropositive status).[14]. Here, AQP4 is linked to neuromyelitis optica.