DPYSL5 and neuromyelitis optica: Other disorders that could have an acute opticospinal presentation include acute disseminated encephalomyelitis, lymphoma, SLE, Sjögren's syndrome, and herpes zoster.[18] CRMP-5/antiCV-2 antibody in association with systemic cancers have been found in patients with an NMO-like presentation.[19, 20] The differential diagnoses of isolated or relapsing optic neuritis or transverse myelitis includes numerous conditions and are summarized elsewhere.[21, 22]