PPARG and obesity due to melanocortin 4 receptor deficiency: Mice with genetic deletion of PPARγ in skeletal muscle showed significantly increased whole-body insulin resistance [59, 60, 100], demonstrated either by insulin/glucose tolerance tests or by hyperinsulinemic euglycemic clamp studies, and developed dyslipidaemia, enlarged fat pads, and obesity on high-fat diet [59, 60].