Efforts have been made to find molecules of HCC progression and metastasis, including Alpha-fetoprotein (AFP) [20], Alpha-fetoprotein-L3 (AFPR-L3) [21], des-g-carboxy-prothrombin (DCP) [22], a-Fucosidase [23], Glypican-3 [24], transforming growth factor-b1 (TGFβ) [25], insulin-like growth factor-II (IGF-II) [26], insulin-like growth factor-binding protein-2 (IGFBP-2) [27], human cervical cancer oncogene (HCCR) [28], Golgi protein 73 (GP73) [29], hepatocyte growth factor (HGF) [30], KL-6 [31], vascular endothelial growth factor (VEGF) [32], and tumor-associated antigens (TAAs) [33]. The gene discussed is LETMD1; the disease is hepatocellular carcinoma.