BIRC5 and neoplasm: Patients of group 3 with a moderate or strong survivin staining in the cytoplasm and a moderate survivin expression in the nucleus possessed an additive significantly increased risk of tumor-related death (24.8-fold; P = 0.003; Table 2, Fig. 2C) compared to patients (group1) with a weak expression of survivin both in cytoplasm and nucleus in their tumors.