Of the 63 duplicate, paired clinical samples obtained from matched-biopsies before and after treatment with the mTOR inhibitor RAD001, 42 were of sufficient quality to be used in an analysis to reveal differentially expressed genes (Sabine VS, Sims AH, Macaskill EJ, Renshaw L, Thomas JS, Dixon JM, Bartlett JMS: Gene Expression Profiling of Response to mTOR Inhibitor Everolimus in Pre-operatively Treated Post-menopausal Women with Estrogen Receptor-Positive Breast Cancer, Submitted). This evidence concerns the gene MTOR and breast carcinoma.