In our large clinical population followed for almost a decade, we have shown that HNC patients who have the combined tumor markers which individually are associated with better prognosis, p16+, p53-, and HPV-HR, also have the best clinical outcomes whereas those with the opposite status markers, p16-, p53+, and HPV-, have the worst disease-specific and recurrence-free survival. The gene discussed is CDKN2A; the disease is neoplasm.