Later stage (IV, OR = 2.6, 1.2-5.7) and higher grade (OR = 2.0, 0.97-4.3) were more likely to be detected in p16+, and positive nodal involvement was more frequently found in p16+ (OR = 2.1, 1.05-4.0) and HPV-HR (OR = 2.1, 0.99-4.4) cancers. This evidence concerns the gene CDKN2A and cancer.