VWF and hypothyroidism: In brief, milder forms of hypothyroidism may present with abnormalities resembling von Willenbrand's disease [3], i.e. decreased platelet adhesives, abnormal bleeding times, decreased levels of factors VIII, IX, XI and XII and a state with low von Willebrandt factor (vWF) activity [3], while severe hypothyroidism may result in a hypocoagulable state as shown by increases in platelet and factor VII as well as by decreases in fibrinolytic activity [4].