Horne et al. [5] demonstrated higher concentrations of prothrombin fragment 1 + 2, fibrynogen, factor VIII, antithrombin, tissue plasminogen activator antigen (tPA), plasminogen activator inhibitor 1 (PAI-1), PAI-1/tPA ratio and C-reactive protein in subjects with a history of cured thyroid cancer receiving standard TSH-suppressive L-thyroxine therapy in comparison to concentrations of the above parameters measured in the same subjects in a hypothyroid phase prior to radioiodine whole-body scanning procedure. This evidence concerns the gene SERPINE1 and thyroid gland carcinoma.