It is tempting to speculate that the lymph node metastasis of case 1 and the intracranial metastasis of case 2 show E-cadherin expression due to the reverse process of EMT: mesenchymal-epithelial transition (MET; also epithelial-mesenchymal reverting transition, EMrT). The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.