Cheung et al recommended using a panel of CK19, HBME-1 and Ret as a useful means for diagnosing papillary carcinoma; whereas Rossie et al concluded that a panel of only HBME-1 and galectin-3 can correctly diagnose classic and variants of papillary carcinomas. The gene discussed is LGALS3; the disease is thyroid gland papillary carcinoma.