LGALS3 and cancer: We also found that combination panels of 2 or 3 of these markers (galectin-3+ HBME-1; galectin-3+ CK19; HBME-1+ CK19 or galectin-3+ HBME-1+ CK19) do not significantly improves the sensitivity or specificity of immunoexpression in malignant tumors.