Also MCP-1 serum level (fig 2C), displayed a statistically significative decrease in old Down's syndrome patients (103.78 ± 42.11 SD pg/mL) compared to children Down's syndrome patients (252.09 ± 91.06 SD pg/mL, p < 0.001) while it showed a not statistically significative decrease compared to adults Down's syndrome patients (174.99 ± 62.29 SD pg/mL, p > 0.05). The gene discussed is CCL2; the disease is Down syndrome.