The latter corresponds to a coding polymorphism (Asn107Ile) that affects NPSR1 expression and NPS efficacy,[17], [18] and which has been linked to airway hyperresponsivenes in Chinese asthmatics.[19] However, this SNP only shows association of nominal significance with ACPA-negative RA in our study. The gene discussed is NPSR1; the disease is rheumatoid arthritis.