Secord and associates reported that the incidence of opportunistic infection and failure to thrive was lower in children with HIV-1 infection and high IgE levels than it was in HIV-1 infected children with low or normal IgE levels and similar decreases in CD4+ T lymphocyte counts; IgE anti-HIV antibody was detected in 43% of the children with high IgE levels[14]. The gene discussed is IGHE; the disease is Opportunistic infection.