Boehmdenf et al. [11]also showed that Bcl-xl expression in head and neck squamous cell carcinoma was significantly different among different types of pathological grading, while the expression of Bcl-xl protein in human prostate cancer specimens was closely correlated with the Gleason scoring and metastasis of human prostate cancers[12]. This evidence concerns the gene BCL2L1 and Familial prostate cancer.