To verify this hypothesis, we examined the expression of PSM2 protein in cervical cancer in this study, evaluated the effects of cisplatin on PMS2 expression in HeLa cells, and examined the importance of GSK-3β binding on PMS2 stability and chemosensitization to cisplatin in HeLa cells by taking advantage of co-immunoprecipitation (IP), small interference RNA (siRNA) and flow cytometric analysis. This evidence concerns the gene GSK3B and cervical carcinoma.