It is well known that chemosensitization to chemotherapeutic agents usually is thought to result from apoptosis induction and functional MMR and drug resistance is associated with MMR deficiency, we thus postulated that treatment with cisplatin on HeLa cells may result in an MMR response and PMS2 upregulation. This evidence concerns the gene PMS2 and hyperinsulinemic hypoglycemia, familial, 4.