MDM2 and non-small cell lung carcinoma: Using MDM2 antagonist nutlin-3 as selective activator of p53 pathway, we have shown that induction of cell cycle arrest can protect p53wt NSCLC (A549) cells from the cytotoxicity of taxol selectively killing of p53-/- PSCC cells (FaDu) and p53-/- NSCLC (H1299) cells.