The results show that both CD7 and ELA2 CpG-rich regions are significantly associated with acetylated histones in the positive cell lines (ALL-SIL and THP-1, respectively) at levels as high as, or higher than, the positive control region of HPRT. In contrast, there is relatively little association of acetylated histones with the CpG-rich region of CD7 and ELA2 in the negative cell lines (THP-1 and ALL-SIL, respectively). Here, ELANE is linked to acute lymphoblastic leukemia.