One is the gene encoding CCDC80/URB/SSG1/DRO1, which was identified as an upregulated transcript in the adipose tissue of bombesin receptor subtype-3 (BRS-3)-deficient mice displaying mild late-onset obesity [66] and sensitizes cells to anoikis and apoptosis [67]. Here, BRS3 is linked to obesity due to melanocortin 4 receptor deficiency.