However, in the chronic phase of HIV infection, although CD4+ CD25+ Treg cells have been shown to suppress both HIV-specific CD8 and CD4 T-cell functions [12]–[20], including the secretion of CD8 antiviral soluble factors [13], the presence of these cells maybe beneficial in controlling immune activation and subsequent disease progression [16], [17]–[20]. This evidence concerns the gene CD8A and HIV infectious disease.