In support of this contention, Ji & Cloyd (2009) [54] observed that in vitro infection of Treg cells leads to the up-regulation of the homing receptor CD62L and integrin alpha4beta7, and upon injection of HIV and mock infected Treg cells into SCID mice, infected Tregs could be found in higher numbers in lymph nodes and lymphoid tissue. Here, SELL is linked to infection.