Indeed, the decreased presentation of this epitope on the MHC-I (HLA-A*02) complex of antigen presenting cells or other cells involved in MS pathways could reduce the probability to disrupt the physiological tolerance (central or peripheral) of MBP-reactive CD8+ T cells and/or their cytotoxicity towards oligodendrocytes thereby restraining the MS onset. Here, CD8A is linked to myeloid sarcoma.