The data we obtained indicates that immunoproteasomes and PA28-αβ regulator are present in MS CNS and that the LMP2 60HH genotype impinges upon MS, likely in part by reducing the production of a specific HLA-A*02 restricted Myelin Basic Protein epitope (MBP111–119) implicated in MS pathology [13], [14], [15] as shown in in vitro assays and in the presence of PA28-αβ. Here, PSMB9 is linked to myeloid sarcoma.