In males with depression accompanied by early morning awakening (D+EMA+), there was also some evidence of interaction between TIMELESS rs2291739 and ARNTL rs1868049 (P = 0.0006, OR = 4.36), between TIMELESS rs7486220 and RORA rs4774370 (P = 0.003, OR = 3.12), and between TIMELESS rs1082214 and NR1D1 rs2269457 (P = 0.003, OR = 3.97) (Table 5). The gene discussed is NR1D1; the disease is depressive symptom measurement.