NPAS2 rs12712083, as well as a non-synonymous coding SNP located on exon 5 rs2063690 of TIPIN (Ala111Gly), were associated with depression and fatigue (P = 0.045, OR = 0.72 and P = 0.037, OR = 1.71, respectively). Here, NPAS2 is linked to major depressive disorder.