Single-locus analysis of females (n = 967) suggested an association (P<0.05) between depression and depression accompanied by signs of disturbed sleep with 14 SNPs from six circadian-related genes: TIMELESS, ARNTL, RORA, nuclear factor, interleukin 3 regulated (NFIL3), CSNK1E, and CRY2 (Table 1; full data available in Table S1). This evidence concerns the gene TIMELESS and major depressive disorder.