MYD88 and infection: Although we observed 10-fold higher levels of IL-12 in the vhs- infections relative to KOS for cells isolated from mice deficient in TLR3, we suspect that the difference compared to infection of mu-cDCs from wild-type mice and MyD88 single knock-out mice (where TLR3 is present and functional) may be attributable to the function of vhs as a viral nuclease (see below).