PubMed searches suggest apparently similar findings were reported for ‘FVIII antigen’ in human umbilical vein EC [34], [35], but it is important to note that this work referred to an antigen that was present at normal levels in haemophiliac plasma, but at reduced levels in plasma from patients with von Willebrand's disease [35], representing what we would now term VWF:Ag, as described in [36]. This evidence concerns the gene F8 and Von Willebrand disease.