MAPK1 and ovarian carcinoma: Moreover, the ovarian cancer cells typically had higher transcript levels of importin 7 (Imp7) and importin B1 (ImpB1, also known as KPNB1), members of the karyopherin/importin-beta family of nuclear transport factors that have been shown in Drosophila to modulate MAPK/ERK nuclear localization [8], [9], [30], [31].