Protection from malaria attacks was found significantly associated with high anti-MSP3b IgG1 responses [L-R Chisquare = 5.99; P = 0.0143], and independently, with high anti-MSP3b IgG3 responses [L-R Chisquare = 5.33; P = 0.0208]. This evidence concerns the gene IGHG3 and malaria.