Subsequently, we sequenced all of the exons, intron–exon boundaries, and up to 1.2 kb of the promoter region of the KCNQ1 gene in 50 individuals with T2D, and identified 42 polymorphic variations, including one nonsynonymous P448R polymorphism and two novel SNPs with minor allele frequency >0.03. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.