Deficiency of carnitine palmityl transferase-II (CPT-II) – an enzyme that is used for the transportation of fatty acids inside mitochondria – induces migraine, which improves with the administration of carnitine.[23] Furthermore, the blood levels of pyruvic acid and lactic acid are higher in migraineurs than in controls and TTH subjects, thus providing direct evidence of mitochondrial dysfunction in migraineurs.[24] Hence, there is enough evidence to support the theory that migraineurs have higher oxidant levels. This evidence concerns the gene CPT2 and migraine disorder.