Indeed, experimental evidence supports a relation between A1AT deficiency and DILI as administration of indomethacin in a homozygous Pi ZZ mouse model leads to increased hepatic injury [20] and a case report described prochlorperazine induced liver injury in a homozygous (Pi ZZ) A1AT deficient patient [21]. Here, SERPINA1 is linked to hyperinsulinemic hypoglycemia, familial, 4.