For example, the combination of angiotensinogen (ATG) gene variant c.1-44 and transforming growth factor beta (TGFβ1) p.R25P is associated with advanced hepatic fibrosis in obese patients with non alcoholic fatty liver disease [22] but not in patients with other chronic liver diseases[23]. The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatotic liver disease.