CDKN1B and cancer: It is known that a relatively large number of nutritional and chemopreventive anti-cancer agents specifically up-regulate expression of p27 in eukaryotic cells without directly affecting other G1-to-S phase cell cycle regulatory proteins including INK4s, p57(Kip2), p21(Cip1Waf1), D-type cyclins, cyclin E, cyclin A, CDK2, CDK4 and CDK6 [9,10].