AKT1 and cancer: The second most notable result of this study was the expression of the following two proteins which were significantly up or down-regulated by one or more of these anti-cancer agents tested: (a) one was AMPKα (5'-AMP-activated protein kinase α) phosphorylated at Thr172 (Figure 5f) and (b) another was Akt/PKB phosphorylated at Thr308 (Figure 6b).