Nadal et al.11found that six out of seven laryngeal tumors of grade IV presented low levels of CDKN1A, compared with 41 out of 42 tumors of grade I to III, which presented intermediate levels of CDKN1A. There is controversy regarding the prognostic value of CDKN1A expression in breast tissue. Here, CDKN1A is linked to laryngeal neoplasm.