In pattern two, in contrast, both COX-2 inhibitor treatment and COX-2 knockdown reduced KSHV induced VEGF-A and VEGF-C gene expression significantly at both early and late time points (Figures 5B and S6A), thus suggesting a role for KSHV induced COX-2 in the regulation of VEGF-A and -C at all time points of infection. This evidence concerns the gene PTGS2 and infection.