When we tested this hypothesis by using chemical inhibitors of COX-2 or by COX-2 silencing, we uncovered evidence for the role of COX-2/PGE2 in viral latent gene expression, in pro-inflammatory, angiogenic and invasive events occurring during KSHV de novo infection of endothelial cells as well as the survival of latently infected endothelial cells. This evidence concerns the gene PTGS2 and infection.